Version 5.4
Bos taurus Gene: BCLAF1
Summary
InnateDB Gene IDBG-633603.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCLAF1
Gene Name bcl-2-associated transcription factor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007802
Encoded Proteins
IDBP-685323
bcl-2-associated transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000029363:
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:75262831-75291455
Strand Reverse strand
Band
Transcripts
ENSBTAT00000052712 ENSBTAP00000052174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043620 regulation of DNA-dependent transcription in response to stress
GO:0045892 negative regulation of transcription, DNA-templated
GO:2000144 positive regulation of DNA-dependent transcription, initiation
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000029363
View Gene Order
ENSMUSG00000037608
View Gene Order
Cross-References
SwissProt
TrEMBL F1MQU4
UniProt Splice Variant
Entrez Gene 540648
UniGene Bt.14278
RefSeq NM_001098117 XM_005210974
HUGO HGNC:16863
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02026731
GenPept
RNA Seq Atlas 540648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca