InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FBXW8

Summary

InnateDB Gene

IDBG-633635.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW8

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000036183

Encoded Proteins

IDBP-685370

F-box and WD repeat domain containing 8

IDBP-685375

F-box and WD repeat domain containing 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174989:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:60338777-60396323

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064959	ENSBTAP00000056288
ENSBTAT00000050675	ENSBTAP00000047345

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0060712	spongiotrophoblast layer development
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005794	Golgi apparatus
GO:0019005	SCF ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex