Version 5.4
Bos taurus Gene: GRHPR
Summary
InnateDB Gene IDBG-633727.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRHPR
Gene Name glyoxylate reductase/hydroxypyruvate reductase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019299
Encoded Proteins
IDBP-685447
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137106:
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:61942616-61951512
Strand Forward strand
Band
Transcripts
ENSBTAT00000025697 ENSBTAP00000025697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008465 glycerate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016618 hydroxypyruvate reductase activity
GO:0030267 glyoxylate reductase (NADP) activity
GO:0042803 protein homodimerization activity
GO:0048037 cofactor binding
GO:0051287 NAD binding
GO:0070402 NADPH binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0007588 excretion
GO:0008152 metabolic process
GO:0051259 protein oligomerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137106
View Gene Order
ENSMUSG00000035637
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16925
Glyoxylate metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_261828
Glyoxylate metabolism pathway
KEGG
hsa00620
Pyruvate metabolism pathway
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00620
Pyruvate metabolism pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001192037 XM_002693915
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca