InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRHPR

Summary

InnateDB Gene

IDBG-65625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRHPR

Gene Name

glyoxylate reductase/hydroxypyruvate reductase

Synonyms

GLXR; GLYD; PH2

Species

Homo sapiens

Ensembl Gene

ENSG00000137106

Encoded Proteins

IDBP-65627

glyoxylate reductase/hydroxypyruvate reductase

IDBP-584526

glyoxylate reductase/hydroxypyruvate reductase

IDBP-811505

glyoxylate reductase/hydroxypyruvate reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:37422666-37436990

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000318158	ENSP00000313432
ENST00000377824
ENST00000493368
ENST00000460882
ENST00000487399
ENST00000491488
ENST00000497693
ENST00000480596
ENST00000494290	ENSP00000432021
ENST00000482603
ENST00000607784	ENSP00000475569

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008465	glycerate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016618	hydroxypyruvate reductase activity
GO:0030267	glyoxylate reductase (NADP) activity
GO:0031406	carboxylic acid binding
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding
GO:0050661	NADP binding
GO:0051287	NAD binding
GO:0070402	NADPH binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0007588	excretion
GO:0008152	metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0043648	dicarboxylic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0046487	glyoxylate metabolic process
GO:0051259	protein oligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035637

View Gene Order

ENSBTAG00000019299

Not yet available

Pathways

NETPATH

REACTOME

REACT_16925

Glyoxylate metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00620

Pyruvate metabolism pathway

hsa00260

Glycine, serine and threonine metabolism pathway

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.155742

RefSeq

NM_012203

HUGO

OMIM

CCDS

CCDS6609

HPRD

05052

IMGT

EMBL

GenPept

RNA Seq Atlas