Homo sapiens Gene: GRHPR
Summary
InnateDB Gene IDBG-65625.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRHPR
Gene Name glyoxylate reductase/hydroxypyruvate reductase
Synonyms GLXR; GLYD; PH2;
Species Homo sapiens
Ensembl Gene ENSG00000137106
Encoded Proteins
glyoxylate reductase/hydroxypyruvate reductase
glyoxylate reductase/hydroxypyruvate reductase
glyoxylate reductase/hydroxypyruvate reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:37422666-37436990
Strand Forward strand
Band p13.2
Transcripts
ENST00000318158 ENSP00000313432
ENST00000377824
ENST00000493368
ENST00000460882
ENST00000487399
ENST00000491488
ENST00000497693
ENST00000480596
ENST00000494290 ENSP00000432021
ENST00000482603
ENST00000607784 ENSP00000475569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 13 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008465 glycerate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016618 hydroxypyruvate reductase activity
GO:0030267 glyoxylate reductase (NADP) activity
GO:0031406 carboxylic acid binding
GO:0042803 protein homodimerization activity
GO:0048037 cofactor binding
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0070402 NADPH binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0007588 excretion
GO:0008152 metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0043648 dicarboxylic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0046487 glyoxylate metabolic process
GO:0051259 protein oligomerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Glyoxylate metabolism pathway
Metabolism pathway
KEGG
Glycine, serine and threonine metabolism pathway
Pyruvate metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL U3KQ56
UniProt Splice Variant
Entrez Gene 9380
UniGene
RefSeq NM_012203
HUGO HGNC:4570
OMIM 604296
CCDS CCDS6609
HPRD
IMGT
EMBL AL158155
GenPept
RNA Seq Atlas 9380