Version 5.4
Bos taurus Gene: ADAM22
Summary
InnateDB Gene IDBG-633802.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM22
Gene Name disintegrin and metalloproteinase domain-containing protein 22 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007136
Encoded Proteins
IDBP-685541
ADAM metallopeptidase domain 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008277:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:72691793-72763460
Strand Forward strand
Band
Transcripts
ENSBTAT00000009397 ENSBTAP00000009397
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008344 adult locomotory behavior
GO:0014037 Schwann cell differentiation
GO:0022011 myelination in peripheral nervous system
GO:0042063 gliogenesis
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000008277
View Gene Order
ENSMUSG00000040537
View Gene Order
Cross-References
SwissProt
TrEMBL F1MY31
UniProt Splice Variant
Entrez Gene 523645
UniGene Bt.106429
RefSeq NM_001191131
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02011019 DAAA02011020 DAAA02011021 DAAA02011022
GenPept
RNA Seq Atlas 523645

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca