InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNNT2

Summary

InnateDB Gene

IDBG-634165.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNT2

Gene Name

troponin T, cardiac muscle

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000045789

Encoded Proteins

IDBP-685940

troponin T, cardiac muscle

IDBP-685944

troponin T, cardiac muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118194:
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:49259287-49262028

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064811	ENSBTAP00000054984
ENSBTAT00000065361	ENSBTAP00000055971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005523	tropomyosin binding
GO:0016887	ATPase activity
GO:0030172	troponin C binding
GO:0031013	troponin I binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006936	muscle contraction
GO:0006937	regulation of muscle contraction
GO:0007507	heart development
GO:0008016	regulation of heart contraction
GO:0030049	muscle filament sliding
GO:0032780	negative regulation of ATPase activity
GO:0032781	positive regulation of ATPase activity
GO:0045214	sarcomere organization
GO:0051592	response to calcium ion
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis