|Bos taurus Gene: REL|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||proto-oncogene c-Rel|
v-rel reticuloendotheliosis viral oncogene homolog (avian)
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Homo sapiens] Essential for the development of innate and T-cell-induced colitis through its ability to modulate expression of IL-12/23 family members
[Mus musculus] Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162924:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008]
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin\'s lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
|Genomic Location||Chromosome 11:43500946-43527753|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Atypical NF-kappaB pathway
Regulation of Androgen receptor activity
|UniProt Splice Variant|
|RefSeq||NM_001192970 XM_005212596 XM_005212597 XM_005212598|
|RNA Seq Atlas|
|Tag Count based mRNA-Abundances across 87 different Tissues (TPM).
Based on Data from Bovine Gene Atlas
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