Mus musculus Gene: Rel
Summary
InnateDB Gene IDBG-155648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rel
Gene Name reticuloendotheliosis oncogene
Synonyms c-Rel;
Species Mus musculus
Ensembl Gene ENSMUSG00000020275
Encoded Proteins
reticuloendotheliosis oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Essential for the development of innate and T-cell-induced colitis through its ability to modulate expression of IL-12/23 family members
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162924:
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008]
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin\'s lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:23741514-23770970
Strand Reverse strand
Band A3.2
Transcripts
ENSMUST00000102864 ENSMUSP00000099928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 23 [view]
Protein-DNA 34 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001816 cytokine production
GO:0006355 regulation of transcription, DNA-templated
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1901215 negative regulation of neuron death
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
RANKL pathway
Leptin pathway
REACTOME
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Atypical NF-kappaB pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL A4QPD3
UniProt Splice Variant
Entrez Gene 19696
UniGene
RefSeq NM_009044
OMIM
CCDS CCDS24480
HPRD
IMGT
MGI ID MGI:97897
MGI Symbol Rel
EMBL AL805916 BC139447 BC139448 BC139770 CH466595
GenPept AAI39448 AAI39449 AAI39771 EDL07897
RNA Seq Atlas 19696