Bos taurus Gene: LPL
Summary
InnateDB Gene IDBG-634385.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPL
Gene Name Lipoprotein lipase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012855
Encoded Proteins
Lipoprotein lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175445:
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67481089-67511227
Strand Forward strand
Band
Transcripts
ENSBTAT00000017086 ENSBTAP00000017086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004465 lipoprotein lipase activity
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016787 hydrolase activity
GO:0034185 apolipoprotein binding
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0010890 positive regulation of sequestering of triglyceride
GO:0016042 lipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0034361 very-low-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chylomicron-mediated lipid transport pathway
Retinoid metabolism and transport pathway
Lipoprotein metabolism pathway
Visual phototransduction pathway
Transcriptional regulation of white adipocyte differentiation pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Disease pathway
Developmental Biology pathway
Lipid digestion, mobilization, and transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
Retinoid metabolism and transport pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Lipoprotein metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Disease pathway
Chylomicron-mediated lipid transport pathway
Transcriptional regulation of white adipocyte differentiation pathway
Disease pathway
Retinoid metabolism and transport pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Chylomicron-mediated lipid transport pathway
Lipoprotein metabolism pathway
Developmental Biology pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
KEGG
Glycerolipid metabolism pathway
PPAR signaling pathway pathway
Alzheimer's disease pathway
Glycerolipid metabolism pathway
PPAR signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Visceral fat deposits and the metabolic syndrome [Biocarta view]
Role of ppar-gamma coactivators in obesity and thermogenesis [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.5387
RefSeq NM_001075120
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas