InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPL

Summary

InnateDB Gene

IDBG-9632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPL

Gene Name

lipoprotein lipase

Synonyms

HDLCQ11; LIPD

Species

Homo sapiens

Ensembl Gene

ENSG00000175445

Encoded Proteins

IDBP-9634

lipoprotein lipase

IDBP-475593

lipoprotein lipase

IDBP-478487

lipoprotein lipase

IDBP-484843

lipoprotein lipase

IDBP-479111

lipoprotein lipase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:19901717-19967258

Strand

Forward strand

Band

p21.3

Transcripts

ENST00000311322	ENSP00000309757
ENST00000520959	ENSP00000428496
ENST00000524029	ENSP00000428237
ENST00000522701	ENSP00000428557
ENST00000519773	ENSP00000431028
ENST00000521994
ENST00000523696

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004465	lipoprotein lipase activity
GO:0004620	phospholipase activity
GO:0004806	triglyceride lipase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017129	triglyceride binding
GO:0034185	apolipoprotein binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006641	triglyceride metabolic process
GO:0006644	phospholipid metabolic process
GO:0007603	phototransduction, visible light
GO:0009409	response to cold
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0010890	positive regulation of sequestering of triglyceride
GO:0016042	lipid catabolic process
GO:0019432	triglyceride biosynthetic process
GO:0019433	triglyceride catabolic process
GO:0034371	chylomicron remodeling
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0031225	anchored component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome