InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.41985

Summary

InnateDB Gene

IDBG-634403.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.41985

Gene Name

katanin p60 ATPase-containing subunit A1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032024

Encoded Proteins

IDBP-686179

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186625:
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:87965071-87999503

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001172

ENSBTAP00000001172

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001578	microtubule bundle formation
GO:0001764	neuron migration
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007049	cell cycle
GO:0007126	meiotic nuclear division
GO:0008104	protein localization
GO:0031122	cytoplasmic microtubule organization
GO:0051013	microtubule severing
GO:0051301	cell division
GO:0051329	interphase of mitotic cell cycle

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030496	midbody

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000186625

View Gene Order

ENSMUSG00000019794

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

TrEMBL

E1BH39

UniProt Splice Variant

Entrez Gene

506715

UniGene

Bt.41985

RefSeq

NM_001192103 XM_005211032 XM_005211033 XM_005211034

HUGO

HGNC:6216

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02027051

GenPept

RNA Seq Atlas

506715