InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYO3A

Summary

InnateDB Gene

IDBG-63447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO3A

Gene Name

myosin IIIA

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000095777

Encoded Proteins

IDBP-63449

myosin IIIA

IDBP-63451

myosin IIIA

IDBP-63453

myosin IIIA

IDBP-601371

myosin IIIA

IDBP-808635

myosin IIIA

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:25934267-26212527

Strand

Forward strand

Band

p12.1

Transcripts

ENST00000265944	ENSP00000265944
ENST00000376302	ENSP00000365479
ENST00000376301	ENSP00000365478
ENST00000477691
ENST00000478093
ENST00000543632	ENSP00000445909
ENST00000619592	ENSP00000481939

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding
GO:0060002	plus-end directed microfilament motor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0046777	protein autophosphorylation
GO:0048839	inner ear development
GO:0050896	response to stimulus
GO:0051491	positive regulation of filopodium assembly

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0016459	myosin complex
GO:0030175	filopodium
GO:0031941	filamentous actin
GO:0032426	stereocilium bundle tip
GO:0032433	filopodium tip

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000025716

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000002123

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Cross-References

SwissProt

TrEMBL

B1ANA3

UniProt Splice Variant

Entrez Gene

53904

UniGene

Hs.662630

RefSeq

NM_017433

HUGO

HGNC:7601

OMIM

606808

CCDS

CCDS7148

HPRD

06008

IMGT

EMBL

AL162503 AL358612 AL360217 AL391812

GenPept

RNA Seq Atlas

53904