Homo sapiens Gene: MYO3A
Summary
InnateDB Gene IDBG-63447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYO3A
Gene Name myosin IIIA
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095777
Encoded Proteins
myosin IIIA
myosin IIIA
myosin IIIA
myosin IIIA
myosin IIIA
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:25934267-26212527
Strand Forward strand
Band p12.1
Transcripts
ENST00000265944 ENSP00000265944
ENST00000376302 ENSP00000365479
ENST00000376301 ENSP00000365478
ENST00000477691
ENST00000478093
ENST00000543632 ENSP00000445909
ENST00000619592 ENSP00000481939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030898 actin-dependent ATPase activity
GO:0043531 ADP binding
GO:0051015 actin filament binding
GO:0060002 plus-end directed microfilament motor activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006468 protein phosphorylation
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0046777 protein autophosphorylation
GO:0048839 inner ear development
GO:0050896 response to stimulus
GO:0051491 positive regulation of filopodium assembly
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005737 cytoplasm
GO:0016459 myosin complex
GO:0030175 filopodium
GO:0031941 filamentous actin
GO:0032426 stereocilium bundle tip
GO:0032433 filopodium tip
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL B1ANA3
UniProt Splice Variant
Entrez Gene 53904
UniGene Hs.662630
RefSeq NM_017433
HUGO HGNC:7601
OMIM 606808
CCDS CCDS7148
HPRD 06008
IMGT
EMBL AL162503 AL358612 AL360217 AL391812
GenPept
RNA Seq Atlas 53904