Version 5.4
| Bos taurus Gene: TSHB | |||||
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| Summary | |||||
| InnateDB Gene | IDBG-634605.3 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | TSHB | ||||
| Gene Name | Thyrotropin subunit beta | ||||
| Synonyms | |||||
| Species | Bos taurus | ||||
| Ensembl Gene | ENSBTAG00000006295 | ||||
| Encoded Proteins |
Thyrotropin subunit beta
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||
| Entrez Gene | |||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134200:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene result in congenital hypothyroidism.[provided by RefSeq, Nov 2009] The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto\'s thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
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| Gene Information | |||||
| Type | Protein coding | ||||
| Genomic Location | Chromosome 3:28419563-28424798 | ||||
| Strand | Reverse strand | ||||
| Band | |||||
| Transcripts |
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| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||
| NETPATH | |||||
| REACTOME |
Peptide hormone metabolism pathway
Signaling by GPCR pathway
G alpha (s) signalling events pathway
Glycoprotein hormones pathway
Signal Transduction pathway
Peptide hormone biosynthesis pathway
Metabolism of proteins pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
Hormone ligand-binding receptors pathway
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| KEGG | |||||
| INOH | |||||
| PID NCI | |||||
| Pathway Predictions based on Human Orthology Data | |||||
| NETPATH |
TSH pathway
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| REACTOME |
G alpha (s) signalling events pathway
Hormone ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Glycoprotein hormones pathway
Peptide hormone biosynthesis pathway
Thyroxine biosynthesis pathway
Signaling by GPCR pathway
Amine-derived hormones pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Metabolism of proteins pathway
Metabolism of amino acids and derivatives pathway
GPCR ligand binding pathway
Metabolism pathway
Peptide hormone metabolism pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
Autoimmune thyroid disease pathway
Neuroactive ligand-receptor interaction pathway
Autoimmune thyroid disease pathway
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| INOH |
GPCR signaling pathway
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| PID NCI | |||||
| Cross-References | |||||
| SwissProt | P01223 | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 281552 | ||||
| UniGene | Bt.475 | ||||
| RefSeq | NM_174205 XM_005204003 XM_005204004 XM_005204005 XM_005204006 | ||||
| HUGO | |||||
| OMIM | |||||
| CCDS | |||||
| HPRD | |||||
| IMGT | |||||
| EMBL | K01939 | ||||
| GenPept | AAA30796 | ||||
| RNA Seq Atlas | 281552 | ||||