InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADIPOQ

Summary

InnateDB Gene

IDBG-634641.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADIPOQ

Gene Name

Adiponectin

Synonyms

ACRP30; APM1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019813

Encoded Proteins

IDBP-686417

Adiponectin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18179772

[Homo sapiens] ADIPOQ binds to C1Q and activates the classical pathway of complement.

PMID 22948153

[Homo sapiens] ADIPOQ can induce pro-inflammatory functions in macrophages and T cells.

PMID 22948153

[Mus musculus] ADIPOQ can induce pro-inflammatory functions in macrophages and T cells. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181092:
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:81005168-81018328

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026395

ENSBTAP00000026395

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0033691	sialic acid binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006006	glucose metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0009749	response to glucose
GO:0009967	positive regulation of signal transduction
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875	positive regulation of cholesterol efflux
GO:0010906	regulation of glucose metabolic process
GO:0014912	negative regulation of smooth muscle cell migration
GO:0019395	fatty acid oxidation
GO:0030336	negative regulation of cell migration
GO:0030853	negative regulation of granulocyte differentiation
GO:0031953	negative regulation of protein autophosphorylation
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032757	positive regulation of interleukin-8 production
GO:0032869	cellular response to insulin stimulus
GO:0033034	positive regulation of myeloid cell apoptotic process
GO:0033211	adiponectin-activated signaling pathway
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0034383	low-density lipoprotein particle clearance
GO:0034612	response to tumor necrosis factor
GO:0035690	cellular response to drug
GO:0042593	glucose homeostasis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0045599	negative regulation of fat cell differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045721	negative regulation of gluconeogenesis
GO:0045776	negative regulation of blood pressure
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045923	positive regulation of fatty acid metabolic process
GO:0046326	positive regulation of glucose import
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050765	negative regulation of phagocytosis
GO:0050805	negative regulation of synaptic transmission
GO:0050873	brown fat cell differentiation
GO:0051260	protein homooligomerization
GO:0070208	protein heterotrimerization
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070994	detection of oxidative stress
GO:0071639	positive regulation of monocyte chemotactic protein-1 production
GO:0072659	protein localization to plasma membrane
GO:0090317	negative regulation of intracellular protein transport
GO:1900121	negative regulation of receptor binding
GO:2000279	negative regulation of DNA biosynthetic process
GO:2000467	positive regulation of glycogen (starch) synthase activity
GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development
GO:2000481	positive regulation of cAMP-dependent protein kinase activity
GO:2000534	positive regulation of renal albumin absorption
GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000590	negative regulation of metanephric mesenchymal cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0009986	cell surface
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery