Version 5.4
Homo sapiens Gene: ADIPOQ
Summary
InnateDB Gene IDBG-69167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADIPOQ
Gene Name adiponectin, C1Q and collagen domain containing
Synonyms ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
Species Homo sapiens
Ensembl Gene ENSG00000181092
Encoded Proteins
IDBP-69169
adiponectin, C1Q and collagen domain containing
IDBP-386456
adiponectin, C1Q and collagen domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18179772
ADIPOQ binds to C1Q and activates the classical pathway of complement.
PMID 22948153
ADIPOQ can induce pro-inflammatory functions in macrophages and T cells.
InnateDB Annotation from Orthologs
Summary
PMID 22948153
[Mus musculus] ADIPOQ can induce pro-inflammatory functions in macrophages and T cells. (Demonstrated in human)
Entrez Gene
Summary This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:186842690-186858463
Strand Forward strand
Band q27.3
Transcripts
ENST00000320741 ENSP00000320709
ENST00000444204 ENSP00000389814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0033691 sialic acid binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006635 fatty acid beta-oxidation
GO:0007584 response to nutrient
GO:0007623 circadian rhythm
GO:0009744 response to sucrose stimulus
GO:0009749 response to glucose
GO:0009967 positive regulation of signal transduction
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010739 positive regulation of protein kinase A signaling
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010875 positive regulation of cholesterol efflux
GO:0010906 regulation of glucose metabolic process
GO:0014823 response to activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0019395 fatty acid oxidation
GO:0030336 negative regulation of cell migration
GO:0030853 negative regulation of granulocyte differentiation
GO:0031667 response to nutrient levels
GO:0031953 negative regulation of protein autophosphorylation
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032757 positive regulation of interleukin-8 production
GO:0032869 cellular response to insulin stimulus
GO:0033034 positive regulation of myeloid cell apoptotic process
GO:0033211 adiponectin-activated signaling pathway
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034383 low-density lipoprotein particle clearance
GO:0034612 response to tumor necrosis factor
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407 negative regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045599 negative regulation of fat cell differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045721 negative regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0046326 positive regulation of glucose import
GO:0046888 negative regulation of hormone secretion
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050765 negative regulation of phagocytosis
GO:0050805 negative regulation of synaptic transmission
GO:0050873 brown fat cell differentiation
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0051899 membrane depolarization
GO:0060081 membrane hyperpolarization
GO:0070208 protein heterotrimerization
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070543 response to linoleic acid
GO:0070994 detection of oxidative stress
GO:0071320 cellular response to cAMP
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0071872 cellular response to epinephrine stimulus
GO:0072659 protein localization to plasma membrane
GO:0090317 negative regulation of intracellular protein transport
GO:1900121 negative regulation of receptor binding
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000467 positive regulation of glycogen (starch) synthase activity
GO:2000478 positive regulation of metanephric glomerular visceral epithelial cell development
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000534 positive regulation of renal albumin absorption
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
GO:2000590 negative regulation of metanephric mesenchymal cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022878
View Gene Order
ENSBTAG00000019813
Not yet available
Pathways
NETPATH
REACTOME
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q15848
TrEMBL A8K660
UniProt Splice Variant
Entrez Gene 9370
UniGene Hs.80485
RefSeq NM_004797 NM_001177800
HUGO HGNC:13633
OMIM 605441
CCDS CCDS3284
HPRD 05671
IMGT
EMBL AB012165 AJ131460 AJ131461 AK291525 BC054496 BC096308 BC096309 BC096310 BC096311 CH471052 D45371 EU420013
GenPept AAH54496 AAH96308 AAH96309 AAH96310 AAH96311 ABZ10942 BAA08227 BAA86716 BAF84214 CAB52413 EAW78165
RNA Seq Atlas 9370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca