Version 5.4
Bos taurus Gene: PXN
Summary
InnateDB Gene IDBG-634721.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PXN
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018108
Encoded Proteins
IDBP-686528
paxillin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089159:
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64818100-64833437
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024101 ENSBTAP00000024101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 182 interaction(s) predicted by orthology.
Predicted by orthology
Total 182 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0017166 vinculin binding
GO:0046872 metal ion binding
GO:0051435 BH4 domain binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008360 regulation of cell shape
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030032 lamellipodium assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0045860 positive regulation of protein kinase activity
GO:0048041 focal adhesion assembly
GO:0048754 branching morphogenesis of an epithelial tube
GO:0060396 growth hormone receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0030027 lamellipodium
GO:0031252 cell leading edge
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000089159
View Gene Order
ENSMUSG00000029528
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_18
IL6 pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20617
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_17044
Muscle contraction pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_227951
Signaling by VEGF pathway
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
REACT_242976
Signaling by EGFR pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_242946
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
REACT_206286
GAB1 signalosome pathway
REACT_188257
Signal Transduction pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_255191
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04370
VEGF signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa04062
Chemokine signaling pathway pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04370
VEGF signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
lysophospholipid_pathway
LPA receptor mediated events
cxcr4_pathway
CXCR4-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
ilk_pathway
Integrin-linked kinase signaling
ephbfwdpathway
EPHB forward signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
a4b7_pathway
a4b7 Integrin signaling
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.91983
RefSeq XM_002694523
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca