Homo sapiens Gene: PXN
Summary
InnateDB Gene IDBG-60317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PXN
Gene Name paxillin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089159
Encoded Proteins
paxillin
paxillin
paxillin
paxillin
paxillin
paxillin
paxillin
paxillin
paxillin
paxillin
paxillin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:120210439-120265771
Strand Reverse strand
Band q24.23
Transcripts
ENST00000228307 ENSP00000228307
ENST00000323871
ENST00000267257 ENSP00000267257
ENST00000424649 ENSP00000391283
ENST00000458477 ENSP00000395536
ENST00000440827
ENST00000536957 ENSP00000443887
ENST00000538144
ENST00000550795 ENSP00000449198
ENST00000547983 ENSP00000446893
ENST00000551327
ENST00000543331 ENSP00000443745
ENST00000546532 ENSP00000447180
ENST00000548912 ENSP00000446607
ENST00000552550 ENSP00000446650
ENST00000547746
ENST00000540221
ENST00000550205
ENST00000547772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 236 [view]
Protein-Protein 236 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0017166 vinculin binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0051435 BH4 domain binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008360 regulation of cell shape
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030032 lamellipodium assembly
GO:0034329 cell junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0045860 positive regulation of protein kinase activity
GO:0048041 focal adhesion assembly
GO:0048754 branching morphogenesis of an epithelial tube
GO:0060396 growth hormone receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0031252 cell leading edge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TCR pathway
IL3 pathway
IL6 pathway
Prolactin pathway
Oncostatin_M pathway
REACTOME
Signaling by EGFR in Cancer pathway
Cell-Cell communication pathway
Cell junction organization pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
Smooth Muscle Contraction pathway
Signal Transduction pathway
VEGFA-VEGFR2 Pathway pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
Muscle contraction pathway
GAB1 signalosome pathway
Cell-extracellular matrix interactions pathway
Disease pathway
KEGG
Chemokine signaling pathway pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Ucalpain and friends in cell spread [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Cell to cell adhesion signaling [Biocarta view]
Integrin signaling pathway [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
CXCR4-mediated signaling events
Integrins in angiogenesis
Alpha9 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinase
IGF1 pathway
Integrin-linked kinase signaling
EPHB forward signaling
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
Fc-epsilon receptor I signaling in mast cells
a4b7 Integrin signaling
Arf6 signaling events
Cross-References
SwissProt P49023
TrEMBL F8W0G0 F8W0K8 F8W1E0
UniProt Splice Variant
Entrez Gene 5829
UniGene Hs.446336
RefSeq NM_001243756 XM_005253913 XM_005253917 NM_001080855 NM_025157 NM_002859 XM_005253916 XM_005253915
HUGO HGNC:9718
OMIM 602505
CCDS CCDS58281 CCDS44997 CCDS44998 CCDS44996
HPRD
IMGT
EMBL AC004263 AK314204 BC136787 BC136794 BC144410 BX648777 D86862 D86863 U14588 U87941 U87942 U87943 U87944 U87945 U87946
GenPept AAC05175 AAC50104 AAD00648 AAI36788 AAI36795 AAI44411 BAA18997 BAA18998 BAG36880 CAI46024
RNA Seq Atlas 5829