Homo sapiens Gene: KIF13A
Summary
InnateDB Gene IDBG-63485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF13A
Gene Name kinesin family member 13A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137177
Encoded Proteins
kinesin family member 13A
kinesin family member 13A
kinesin family member 13A
kinesin family member 13A
kinesin family member 13A
kinesin family member 13A
kinesin family member 13A
kinesin family member 13A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:17759183-17987623
Strand Reverse strand
Band p22.3
Transcripts
ENST00000378843 ENSP00000368120
ENST00000378826 ENSP00000368103
ENST00000259711 ENSP00000259711
ENST00000378814 ENSP00000368091
ENST00000358380 ENSP00000351150
ENST00000502297 ENSP00000425616
ENST00000506044 ENSP00000422808
ENST00000514714
ENST00000503342
ENST00000507576
ENST00000505588
ENST00000502704 ENSP00000425453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0000910 cytokinesis
GO:0006886 intracellular protein transport
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
GO:0008333 endosome to lysosome transport
GO:0032438 melanosome organization
GO:0035459 cargo loading into vesicle
GO:0043001 Golgi to plasma membrane protein transport
GO:0072383 plus-end-directed vesicle transport along microtubule
Cellular Component
GO:0000139 Golgi membrane
GO:0005813 centrosome
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0010008 endosome membrane
GO:0030496 midbody
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H1H9
TrEMBL
UniProt Splice Variant
Entrez Gene 63971
UniGene Hs.609743 Hs.629143 Hs.94499
RefSeq NM_001105567 NM_001105566 NM_001105568 NM_001243423 NM_022113 XM_005249290 XM_005249294
HUGO HGNC:14566
OMIM 605433
CCDS CCDS54967 CCDS47380 CCDS47381 CCDS54968 CCDS58998
HPRD 09256
IMGT
EMBL AJ291578 AJ291579 AL023807 AL138724 AY014403 AY014404 BC062673 BC127115 BC127116
GenPept AAG38890 AAG38891 AAI27116 AAI27117 CAC20442 CAC20443 CAI21670 CAI21671 CAI40947 CAI40948
RNA Seq Atlas 63971