Version 5.4
Bos taurus Gene: BT.32541
Summary
InnateDB Gene IDBG-634861.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.32541
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031958
Encoded Proteins
IDBP-686659
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106304:
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:89154606-89161368
Strand Forward strand
Band
Transcripts
ENSBTAT00000045309 ENSBTAP00000042707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004415 hyalurononglucosaminidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007342 fusion of sperm to egg plasma membrane
GO:0008152 metabolic process
GO:0030214 hyaluronan catabolic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000106304
View Gene Order
ENSMUSG00000029678
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163796
Interaction With Cumulus Cells pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
hsa00531
Glycosaminoglycan degradation pathway
mmu00531
Glycosaminoglycan degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MZM9
UniProt Splice Variant
Entrez Gene 509761
UniGene Bt.32541
RefSeq XM_002686914 XM_586790
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02011427
GenPept
RNA Seq Atlas 509761

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca