Homo sapiens Gene: SPAM1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-39033.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | SPAM1 | ||||||||||||||
Gene Name | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) | ||||||||||||||
Synonyms | HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; PH-20; PH20; SPAG15 | ||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Gene | ENSG00000106304 | ||||||||||||||
Encoded Proteins |
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 7:123925237-123971414 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | q31.32 | ||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Interaction With Cumulus Cells pathway
Fertilization pathway
Reproduction pathway
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KEGG |
Glycosaminoglycan degradation pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | P38567 | ||||||||||||||
TrEMBL | C9J2X5 Q5D1J4 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 6677 | ||||||||||||||
UniGene | Hs.121494 Hs.642293 | ||||||||||||||
RefSeq | NM_001174045 NM_001174046 NM_001174044 NM_003117 NM_153189 | ||||||||||||||
HUGO | HGNC:11217 | ||||||||||||||
OMIM | 600930 | ||||||||||||||
CCDS | CCDS5791 CCDS5790 | ||||||||||||||
HPRD | 02958 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | AC004690 AK292229 AY920278 AY920279 AY920280 AY920281 BC026163 CH236947 CH471070 EU794686 L13781 S67798 X84347 | ||||||||||||||
GenPept | AAC60607 AAH26163 AAQ96882 AAX13985 AAX13986 AAX13987 AAX13988 ACJ13740 BAF84918 CAA59086 EAL24329 EAL24330 EAW83604 EAW83606 | ||||||||||||||
RNA Seq Atlas | 6677 | ||||||||||||||