Homo sapiens Gene: SPAM1
Summary
InnateDB Gene IDBG-39033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAM1
Gene Name sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Synonyms HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; PH-20; PH20; SPAG15;
Species Homo sapiens
Ensembl Gene ENSG00000106304
Encoded Proteins
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:123925237-123971414
Strand Forward strand
Band q31.32
Transcripts
ENST00000340011 ENSP00000345849
ENST00000223028 ENSP00000223028
ENST00000402183 ENSP00000386028
ENST00000413927 ENSP00000391491
ENST00000439500 ENSP00000402123
ENST00000460182 ENSP00000417934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007155 cell adhesion
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007342 fusion of sperm to egg plasma membrane
GO:0032504 multicellular organism reproduction
GO:0035036 sperm-egg recognition
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Interaction With Cumulus Cells pathway
Fertilization pathway
Reproduction pathway
KEGG
Glycosaminoglycan degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J2X5
UniProt Splice Variant
Entrez Gene 6677
UniGene Hs.121494 Hs.642293
RefSeq NM_001174044 NM_001174045 NM_001174046 NM_003117 NM_153189
HUGO HGNC:11217
OMIM 600930
CCDS CCDS5790 CCDS5791
HPRD 02958
IMGT
EMBL AC004690
GenPept
RNA Seq Atlas 6677