InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FBXO5

Summary

InnateDB Gene

IDBG-634973.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO5

Gene Name

F-box only protein 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021193

Encoded Proteins

IDBP-686772

F-box only protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112029:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:91056939-91067416

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000055097

ENSBTAP00000052733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding

Biological Process

GO:0001556	oocyte maturation
GO:0007057	spindle assembly involved in female meiosis I
GO:0007346	regulation of mitotic cell cycle
GO:0016050	vesicle organization
GO:0040020	regulation of meiosis
GO:0045835	negative regulation of meiosis
GO:0046785	microtubule polymerization
GO:0051225	spindle assembly
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060565	inhibition of mitotic anaphase-promoting complex activity