Homo sapiens Gene: FBXO5
Summary
InnateDB Gene IDBG-98150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO5
Gene Name F-box protein 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112029
Encoded Proteins
F-box protein 5
F-box protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:152970519-152983579
Strand Reverse strand
Band q25.2
Transcripts
ENST00000229758 ENSP00000229758
ENST00000367241 ENSP00000356210
ENST00000477822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 50 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001556 oocyte maturation
GO:0007057 spindle assembly involved in female meiosis I
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0016050 vesicle organization
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0040020 regulation of meiosis
GO:0045835 negative regulation of meiosis
GO:0046785 microtubule polymerization
GO:0051225 spindle assembly
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060565 inhibition of mitotic anaphase-promoting complex activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Phosphorylation of Emi1 pathway
APC/C-mediated degradation of cell cycle proteins pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of mitotic cell cycle pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Mitotic G1-G1/S phases pathway
G1/S Transition pathway
G1/S-Specific Transcription pathway
Cell Cycle pathway
M Phase pathway
E2F mediated regulation of DNA replication pathway
Cell Cycle, Mitotic pathway
Mitotic Metaphase/Anaphase Transition pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Oocyte meiosis pathway
INOH
PID BIOCARTA
PID NCI
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520506 Hs.713801
RefSeq NM_001142522 NM_012177
HUGO
OMIM
CCDS CCDS47501 CCDS5242
HPRD 09348
IMGT
EMBL
GenPept
RNA Seq Atlas