InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXO5

Summary

InnateDB Gene

IDBG-98150.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO5

Gene Name

F-box protein 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112029

Encoded Proteins

IDBP-98152

F-box protein 5

IDBP-98154

F-box protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:152970519-152983579

Strand

Reverse strand

Band

q25.2

Transcripts

ENST00000229758	ENSP00000229758
ENST00000367241	ENSP00000356210
ENST00000477822

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	50 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001556	oocyte maturation
GO:0007057	spindle assembly involved in female meiosis I
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007346	regulation of mitotic cell cycle
GO:0016050	vesicle organization
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0040020	regulation of meiosis
GO:0045835	negative regulation of meiosis
GO:0046785	microtubule polymerization
GO:0051225	spindle assembly
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060565	inhibition of mitotic anaphase-promoting complex activity