Version 5.4
Bos taurus Gene: NOX3
Summary
InnateDB Gene IDBG-635137.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOX3
Gene Name NADPH oxidase 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013551
Encoded Proteins
IDBP-686949
NADPH oxidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074771:
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:93373745-93439133
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018021 ENSBTAP00000018021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0001659 temperature homeostasis
GO:0009590 detection of gravity
GO:0009629 response to gravity
GO:0042554 superoxide anion generation
GO:0048840 otolith development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043020 NADPH oxidase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000074771
View Gene Order
ENSMUSG00000023802
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BFF3
UniProt Splice Variant
Entrez Gene 526999
UniGene Bt.106455
RefSeq NM_001191333
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027260 DAAA02027261
GenPept
RNA Seq Atlas 526999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca