Version 5.4
Homo sapiens Gene: NOX3
Summary
InnateDB Gene IDBG-98305.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOX3
Gene Name NADPH oxidase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000074771
Encoded Proteins
IDBP-98307
NADPH oxidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:155395370-155455903
Strand Reverse strand
Band q25.3
Transcripts
ENST00000159060 ENSP00000159060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0001659 temperature homeostasis
GO:0009590 detection of gravity
GO:0009629 response to gravity
GO:0042554 superoxide anion generation
GO:0048840 otolith development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0043020 NADPH oxidase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023802
View Gene Order
ENSBTAG00000013551
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9HBY0
TrEMBL
UniProt Splice Variant
Entrez Gene 50508
UniGene Hs.247776
RefSeq NM_015718
HUGO HGNC:7890
OMIM 607105
CCDS CCDS5250
HPRD
IMGT
EMBL AF190122 AF229177 AL031773
GenPept AAG15435 AAG17121 CAI19957
RNA Seq Atlas 50508

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca