InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.44249

Summary

InnateDB Gene

IDBG-635237.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.44249

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010111

Encoded Proteins

IDBP-687080

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152284:
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:49507809-49536136

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013336

ENSBTAP00000013336

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008013	beta-catenin binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0016055	Wnt signaling pathway
GO:0048699	generation of neurons
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005667

transcription factor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000152284

View Gene Order

ENSMUSG00000055799

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11063

Degradation of beta-catenin by the destruction complex pathway

REACT_228216

truncated APC mutants destabilize the destruction complex pathway

REACT_200799

binding of TCF/LEF:CTNNB1 to target gene promoters pathway

REACT_228098

AXIN mutants destabilize the destruction complex, activating WNT signaling pathway

REACT_228143

APC truncation mutants are not K63 polyubiquitinated pathway

REACT_228243

AMER1 mutants destabilize the destruction complex pathway

REACT_172761

Ca2+ pathway pathway

REACT_228096

misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway

REACT_228331

Signaling by WNT in cancer pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_228285

AXIN missense mutants destabilize the destruction complex pathway

REACT_11045

Signaling by Wnt pathway

REACT_228196

APC truncation mutants have impaired AXIN binding pathway

REACT_200731

deactivation of the beta-catenin transactivating complex pathway

REACT_228261

T41 mutants of beta-catenin aren't phosphorylated pathway

REACT_111102

Signal Transduction pathway

REACT_228314

misspliced GSK3beta mutants stabilize beta-catenin pathway

REACT_228137

S45 mutants of beta-catenin aren't phosphorylated pathway

REACT_228048

deletions in the AMER1 gene destabilize the destruction complex pathway

REACT_228159

S33 mutants of beta-catenin aren't phosphorylated pathway

REACT_228060

truncations of AMER1 destabilize the destruction complex pathway

REACT_228229

phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway

REACT_200777

TCF dependent signaling in response to WNT pathway

REACT_228106

repression of WNT target genes pathway

REACT_228112

deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway

REACT_228188

RNF mutants show enhanced WNT signaling and proliferation pathway

REACT_228223

TCF7L2 mutants don't bind CTBP pathway

REACT_200753

formation of the beta-catenin:TCF transactivating complex pathway

REACT_228279

XAV939 inhibits tankyrase, stabilizing AXIN pathway

REACT_228251

S37 mutants of beta-catenin aren't phosphorylated pathway

REACT_116125

Disease pathway

KEGG

hsa05221

Acute myeloid leukemia pathway

hsa05210

Colorectal cancer pathway

hsa04310

Wnt signaling pathway pathway

hsa05216

Thyroid cancer pathway

hsa04520

Adherens junction pathway

hsa05213

Endometrial cancer pathway

hsa05215

Prostate cancer pathway

hsa05217

Basal cell carcinoma pathway

hsa04916

Melanogenesis pathway

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

hsa05200

Pathways in cancer pathway

mmu05213

Endometrial cancer pathway

mmu05217

Basal cell carcinoma pathway

mmu05221

Acute myeloid leukemia pathway

mmu04916

Melanogenesis pathway

mmu04310

Wnt signaling pathway pathway

mmu05210

Colorectal cancer pathway

mmu05216

Thyroid cancer pathway

mmu04520

Adherens junction pathway

mmu05215

Prostate cancer pathway

mmu05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

mmu05200

Pathways in cancer pathway

INOH

INOH website

Wnt signaling pathway pathway

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.44249

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas