Version 5.4
Homo sapiens Gene: ID1
Summary
InnateDB Gene IDBG-63543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ID1
Gene Name inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Synonyms bHLHb24; ID
Species Homo sapiens
Ensembl Gene ENSG00000125968
Encoded Proteins
IDBP-63545
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDBP-63547
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:31605283-31606515
Strand Forward strand
Band q11.21
Transcripts
ENST00000376105 ENSP00000365273
ENST00000376112 ENSP00000365280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0006351 transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007507 heart development
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0030509 BMP signaling pathway
GO:0031648 protein destabilization
GO:0032963 collagen metabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043408 regulation of MAPK cascade
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043534 blood vessel endothelial cell migration
GO:0045668 negative regulation of osteoblast differentiation
GO:0045765 regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046677 response to antibiotic
GO:0048514 blood vessel morphogenesis
GO:0060425 lung morphogenesis
GO:0060426 lung vasculature development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042745
View Gene Order
ENSBTAG00000016169
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
alk1pathway
ALK1 signaling events
il3_pathway
IL3-mediated signaling events
Cross-References
SwissProt P41134
TrEMBL
UniProt Splice Variant
Entrez Gene 3397
UniGene Hs.614216
RefSeq NM_002165 NM_181353
HUGO HGNC:5360
OMIM 600349
CCDS CCDS13185 CCDS13186
HPRD
IMGT
EMBL AK291152 AL110115 AL117381 BC000613 BC012420 BT007443 CH471077 D13889 D13890 S78825 S78986 U57645 X77956
GenPept AAB35037 AAB35038 AAC13882 AAC13883 AAH00613 AAH12420 AAP36111 BAA02988 BAA02989 BAF83841 CAA54920 CAC14950 CAI20171 CAI23029 CAI23030 EAW76432 EAW76434
RNA Seq Atlas 3397

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca