Mus musculus Gene: Id1
Summary
InnateDB Gene IDBG-209844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Id1
Gene Name inhibitor of DNA binding 1
Synonyms AI323524; bHLHb24; D2Wsu140e; Idb1;
Species Mus musculus
Ensembl Gene ENSMUSG00000042745
Encoded Proteins
inhibitor of DNA binding 1
inhibitor of DNA binding 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125968:
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:152736251-152737410
Strand Forward strand
Band H1
Transcripts
ENSMUST00000038368 ENSMUSP00000092019
ENSMUST00000109824 ENSMUSP00000105449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001886 endothelial cell morphogenesis
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0030509 BMP signaling pathway
GO:0031648 protein destabilization
GO:0032963 collagen metabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043408 regulation of MAPK cascade
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045668 negative regulation of osteoblast differentiation
GO:0045765 regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046677 response to antibiotic
GO:0060425 lung morphogenesis
GO:0060426 lung vasculature development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Cellular Senescence pathway
KEGG
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
ID pathway
REACTOME
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Cellular Senescence pathway
KEGG
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
ALK1 signaling events
IL3-mediated signaling events
Cross-References
SwissProt P20067
TrEMBL A2AHY3 Q6GTZ3
UniProt Splice Variant
Entrez Gene 15901
UniGene Mm.396346
RefSeq NM_010495 XM_006498791
OMIM
CCDS CCDS16897
HPRD
IMGT
MGI ID MGI:96396
MGI Symbol Id1
EMBL AK008264 AL731857 BC025073 CT010243 M31885 U43884
GenPept AAA37879 AAC52760 AAH25073 BAB25564 CAJ18451
RNA Seq Atlas 15901