Bos taurus Gene: TCP1
Summary
InnateDB Gene IDBG-635458.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCP1
Gene Name T-complex protein 1 subunit alpha
Synonyms CCT; TRiC;
Species Bos taurus
Ensembl Gene ENSBTAG00000002829
Encoded Proteins
T-complex protein 1 subunit alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120438:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:97481824-97492748
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003662 ENSBTAP00000003662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.
Predicted by orthology
Total 97 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000242 pericentriolar material
GO:0001669 acrosomal vesicle
GO:0002199 zona pellucida receptor complex
GO:0005720 nuclear heterochromatin
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Folding of actin by CCT/TriC pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Chaperonin-mediated protein folding pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Folding of actin by CCT/TriC pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Protein folding pathway
Formation of tubulin folding intermediates by CCT/TriC pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G5E531
UniProt Splice Variant
Entrez Gene 512043
UniGene Bt.4585
RefSeq NM_001038086
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027369
GenPept
RNA Seq Atlas 512043
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)