InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KLC1

Summary

InnateDB Gene

IDBG-635471.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLC1

Gene Name

kinesin light chain 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017299

Encoded Proteins

IDBP-687308

kinesin light chain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126214:
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:69896140-69957173

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023001

ENSBTAP00000023001

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding

Biological Process

GO:0008088	axon cargo transport
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005871	kinesin complex
GO:0016020	membrane
GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0035253	ciliary rootlet
GO:0043005	neuron projection
GO:0043227	membrane-bounded organelle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000126214

View Gene Order

ENSMUSG00000021288

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_25201

Kinesins pathway

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.111385

RefSeq

NM_001098915

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas