Version 5.4
Homo sapiens Gene: KLC1
Summary
InnateDB Gene IDBG-21848.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLC1
Gene Name kinesin light chain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000126214
Encoded Proteins
IDBP-21850
kinesin light chain 1
IDBP-21852
kinesin light chain 1
IDBP-21856
kinesin light chain 1
IDBP-21858
kinesin light chain 1
IDBP-21860
kinesin light chain 1
IDBP-21862
kinesin light chain 1
IDBP-378139
kinesin light chain 1
IDBP-378147
kinesin light chain 1
IDBP-586584
kinesin light chain 1
IDBP-596822
kinesin light chain 1
IDBP-591575
kinesin light chain 1
IDBP-594464
kinesin light chain 1
IDBP-590940
kinesin light chain 1
IDBP-589464
kinesin light chain 1
IDBP-587190
kinesin light chain 1
IDBP-585420
kinesin light chain 1
IDBP-597095
kinesin light chain 1
IDBP-591517
kinesin light chain 1
IDBP-590401
kinesin light chain 1
IDBP-584285
kinesin light chain 1
IDBP-599983
kinesin light chain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103561896-103714249
Strand Forward strand
Band q32.33
Transcripts
ENST00000334553 ENSP00000334523
ENST00000380038 ENSP00000369377
ENST00000246489 ENSP00000246489
ENST00000347839 ENSP00000334618
ENST00000348520 ENSP00000341154
ENST00000389744 ENSP00000374394
ENST00000445352 ENSP00000412693
ENST00000452929 ENSP00000414982
ENST00000557172 ENSP00000450786
ENST00000555467
ENST00000557575 ENSP00000450617
ENST00000553286 ENSP00000452487
ENST00000555836 ENSP00000452481
ENST00000554228 ENSP00000450616
ENST00000557450 ENSP00000450648
ENST00000554280 ENSP00000451242
ENST00000537046 ENSP00000441347
ENST00000553325 ENSP00000452167
ENST00000553436 ENSP00000452095
ENST00000555856 ENSP00000451732
ENST00000535194 ENSP00000442554
ENST00000553680
ENST00000538504
ENST00000557143
ENST00000557686 ENSP00000451691
ENST00000556986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0015631 tubulin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007018 microtubule-based movement
GO:0007596 blood coagulation
GO:0008088 axon cargo transport
GO:0008152 metabolic process
GO:0016032 viral process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035418 protein localization to synapse
GO:0035617 stress granule disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030424 axon
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0035253 ciliary rootlet
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043227 membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021288
View Gene Order
ENSBTAG00000017299
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3831
UniGene Hs.734484
RefSeq NM_001130107 NM_005552 NM_182923
HUGO HGNC:6387
OMIM 600025
CCDS CCDS32165 CCDS41996 CCDS45168
HPRD 02489
IMGT
EMBL
GenPept
RNA Seq Atlas 3831

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca