Version 5.4
Bos taurus Gene: CTC1
Summary
InnateDB Gene IDBG-635666.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTC1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007117
Encoded Proteins
IDBP-687593
CTS telomere maintenance complex component 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178971:
This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:28466248-28483634
Strand Reverse strand
Band
Transcripts
ENSBTAT00000044661 ENSBTAP00000042139
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
Biological Process
GO:0000723 telomere maintenance
GO:0006974 cellular response to DNA damage stimulus
GO:0007568 aging
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010833 telomere maintenance via telomere lengthening
GO:0035264 multicellular organism growth
GO:0045740 positive regulation of DNA replication
GO:0048146 positive regulation of fibroblast proliferation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048539 bone marrow development
GO:0051276 chromosome organization
GO:0071425 hematopoietic stem cell proliferation
GO:0090399 replicative senescence
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0070188 Stn1-Ten1 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000178971
View Gene Order
ENSMUSG00000020898
View Gene Order
Cross-References
SwissProt
TrEMBL E1BDX1
UniProt Splice Variant
Entrez Gene 513500
UniGene Bt.58999
RefSeq XM_002695868 XM_005195654 XM_591190
HUGO HGNC:26169
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048814
GenPept
RNA Seq Atlas 513500

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca