Bos taurus Gene: BT.76413
InnateDB Gene IDBG-636881.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.76413
Gene Name histone deacetylase 6
Species Bos taurus
Ensembl Gene ENSBTAG00000013244
Encoded Proteins
histone deacetylase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094631:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:91994292-92013213
Strand Forward strand
ENSBTAT00000017618 ENSBTAP00000017618
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.
Predicted by orthology
Total 138 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0031593 polyubiquitin binding
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043014 alpha-tubulin binding
GO:0043130 ubiquitin binding
GO:0048156 tau protein binding
GO:0048487 beta-tubulin binding
GO:0051879 Hsp90 protein binding
GO:0070840 dynein complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006476 protein deacetylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 misfolded or incompletely synthesized protein catabolic process
GO:0006886 intracellular protein transport
GO:0007026 negative regulation of microtubule depolymerization
GO:0009636 response to toxic substance
GO:0009967 positive regulation of signal transduction
GO:0010033 response to organic substance
GO:0010469 regulation of receptor activity
GO:0010634 positive regulation of epithelial cell migration
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016236 macroautophagy
GO:0016575 histone deacetylation
GO:0032418 lysosome localization
GO:0034983 peptidyl-lysine deacetylation
GO:0035967 cellular response to topologically incorrect protein
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043241 protein complex disassembly
GO:0043242 negative regulation of protein complex disassembly
GO:0045861 negative regulation of proteolysis
GO:0051788 response to misfolded protein
GO:0070201 regulation of establishment of protein localization
GO:0070301 cellular response to hydrogen peroxide
GO:0070842 aggresome assembly
GO:0070845 polyubiquitinated misfolded protein transport
GO:0070846 Hsp90 deacetylation
GO:0070848 response to growth factor
GO:0071218 cellular response to misfolded protein
GO:0090035 positive regulation of chaperone-mediated protein complex assembly
GO:0090042 tubulin deacetylation
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005881 cytoplasmic microtubule
GO:0005901 caveola
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0030286 dynein complex
GO:0030424 axon
GO:0030425 dendrite
GO:0031252 cell leading edge
GO:0043204 perikaryon
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
TNFalpha pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Cellular responses to stress pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Cellular response to heat stress pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
HSF1 activation pathway
Disease pathway
Cellular responses to stress pathway
Cellular response to heat stress pathway
HSF1 activation pathway
TGF-beta signaling pathway
TGF-beta signaling pathway
Signaling events mediated by HDAC Class II
UniProt Splice Variant
Entrez Gene 513602
UniGene Bt.76413
RefSeq NM_001098960 XM_005228118
EMBL DAAA02073074 DAAA02073075
RNA Seq Atlas 513602