Bos taurus Gene: PRKG1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-637097.3 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | PRKG1 | ||||||||||||||||||||||||||||
Gene Name | cGMP-dependent protein kinase 1 | ||||||||||||||||||||||||||||
Synonyms | cGK 1; CGKI; cGKI-beta | ||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000018404 | ||||||||||||||||||||||||||||
Encoded Proteins |
cGMP-dependent protein kinase 1
cGMP-dependent protein kinase 1
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185532:
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 26:6906081-8343629 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Hemostasis pathway
Immune System pathway
Platelet homeostasis pathway
Nitric oxide stimulates guanylate cyclase pathway
cGMP effects pathway
Adaptive Immune System pathway
Rap1 signalling pathway
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KEGG | |||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signal Transduction pathway
Platelet homeostasis pathway
Hemostasis pathway
Signaling by Wnt pathway
beta-catenin independent WNT signaling pathway
Immune System pathway
Rap1 signalling pathway
Ca2+ pathway pathway
cGMP effects pathway
Adaptive Immune System pathway
Nitric oxide stimulates guanylate cyclase pathway
Signal Transduction pathway
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KEGG |
Gap junction pathway
Olfactory transduction pathway
Long-term depression pathway
Vascular smooth muscle contraction pathway
Salivary secretion pathway
Olfactory transduction pathway
Gap junction pathway
Long-term depression pathway
Vascular smooth muscle contraction pathway
Salivary secretion pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | P00516 | ||||||||||||||||||||||||||||
TrEMBL | F1MY76 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 786016 | ||||||||||||||||||||||||||||
UniGene | Bt.9 | ||||||||||||||||||||||||||||
RefSeq | NM_174436 XM_005225353 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | DAAA02058658 DAAA02058659 DAAA02058660 DAAA02058661 DAAA02058662 DAAA02058663 DAAA02058664 DAAA02058665 DAAA02058666 DAAA02058667 DAAA02058668 DAAA02058669 DAAA02058670 DAAA02058671 DAAA02058672 DAAA02058673 DAAA02058674 DAAA02058675 DAAA02058676 DAAA02058677 DAAA02058678 DAAA02058679 DAAA02058680 DAAA02058681 DAAA02058682 DAAA02058683 DAAA02058684 DAAA02058685 DAAA02058686 DAAA02058687 DAAA02058688 DAAA02058689 DAAA02058690 DAAA02058691 DAAA02058692 DAAA02058693 DAAA02058694 DAAA02058695 DAAA02058696 X16086 X54289 Y08961 | ||||||||||||||||||||||||||||
GenPept | CAA34214 CAA38184 CAA70155 | ||||||||||||||||||||||||||||
RNA Seq Atlas | 282004 786016 | ||||||||||||||||||||||||||||