InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BMK

Summary

InnateDB Gene

IDBG-637181.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMK

Gene Name

midkine precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007740

Encoded Proteins

IDBP-689177

midkine (neurite growth-promoting factor 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110492:
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:77249974-77251941

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010178

ENSBTAP00000010178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001662	behavioral fear response
GO:0007614	short-term memory
GO:0009611	response to wounding
GO:0021542	dentate gyrus development
GO:0021681	cerebellar granular layer development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0030421	defecation
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050795	regulation of behavior
GO:1901215	negative regulation of neuron death