Version 5.4
Homo sapiens Gene: MDK
Summary
InnateDB Gene IDBG-41723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDK
Gene Name midkine (neurite growth-promoting factor 2)
Synonyms ARAP; MK; NEGF2
Species Homo sapiens
Ensembl Gene ENSG00000110492
Encoded Proteins
IDBP-41725
midkine (neurite growth-promoting factor 2)
IDBP-239297
midkine (neurite growth-promoting factor 2)
IDBP-239299
midkine (neurite growth-promoting factor 2)
IDBP-239301
midkine (neurite growth-promoting factor 2)
IDBP-293244
midkine (neurite growth-promoting factor 2)
IDBP-293238
midkine (neurite growth-promoting factor 2)
IDBP-372424
midkine (neurite growth-promoting factor 2)
IDBP-589122
midkine (neurite growth-promoting factor 2)
IDBP-586647
midkine (neurite growth-promoting factor 2)
IDBP-811266
midkine (neurite growth-promoting factor 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46380756-46383837
Strand Forward strand
Band p11.2
Transcripts
ENST00000359803 ENSP00000352852
ENST00000395569 ENSP00000378936
ENST00000395566 ENSP00000378933
ENST00000395565 ENSP00000378932
ENST00000405308 ENSP00000385451
ENST00000407067 ENSP00000384034
ENST00000441869 ENSP00000416241
ENST00000490240
ENST00000481047
ENST00000489525 ENSP00000433240
ENST00000533952 ENSP00000432649
ENST00000533283
ENST00000617138 ENSP00000480875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0008201 heparin binding
Biological Process
GO:0001662 behavioral fear response
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0007614 short-term memory
GO:0009611 response to wounding
GO:0009725 response to hormone
GO:0016477 cell migration
GO:0021542 dentate gyrus development
GO:0021681 cerebellar granular layer development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030325 adrenal gland development
GO:0030421 defecation
GO:0042493 response to drug
GO:0043524 negative regulation of neuron apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050795 regulation of behavior
GO:0051384 response to glucocorticoid
GO:0051781 positive regulation of cell division
GO:1901215 negative regulation of neuron death
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027239
View Gene Order
ENSBTAG00000007740
Not yet available
Pathways
NETPATH
REACTOME
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_299
Signaling by NOTCH pathway
KEGG
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
syndecan_4_pathway
Syndecan-4-mediated signaling events
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
glypican_2pathway
Glypican 2 network
Cross-References
SwissProt P21741
TrEMBL C9JHA4 E9PPJ5
UniProt Splice Variant
Entrez Gene 4192
UniGene
RefSeq NM_002391 NM_001012333 NM_001012334 NM_001270550 NM_001270551 NM_001270552
HUGO HGNC:6972
OMIM 162096
CCDS CCDS7919 CCDS59226
HPRD 01200
IMGT
EMBL AC116021 BC011704 D10604 DQ323888 M69148 M94250 X55110
GenPept AAA58478 AAA59850 AAH11704 ABC55425 BAA01457 CAA38908
RNA Seq Atlas 4192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca