InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FAS

Summary

InnateDB Gene

IDBG-637356.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAS

Gene Name

Tumor necrosis factor receptor superfamily member 6

Synonyms

APO1; TNFRSF6

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010785

Encoded Proteins

IDBP-689361

Tumor necrosis factor receptor superfamily member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000026103:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:10714132-10748014

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014282

ENSBTAP00000014282

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0042802	identical protein binding

Biological Process

GO:0002377	immunoglobulin production
GO:0003014	renal system process
GO:0006915	apoptotic process
GO:0006924	activation-induced cell death of T cells
GO:0006925	inflammatory cell apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007623	circadian rhythm
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636	response to toxic substance
GO:0010467	gene expression
GO:0019724	B cell mediated immunity
GO:0032464	positive regulation of protein homooligomerization
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045060	negative thymic T cell selection
GO:0045619	regulation of lymphocyte differentiation
GO:0045637	regulation of myeloid cell differentiation
GO:0048536	spleen development
GO:0050869	negative regulation of B cell activation
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0051402	neuron apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:0071285	cellular response to lithium ion
GO:0071455	cellular response to hyperoxia
GO:0097049	motor neuron apoptotic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097527	necroptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome