InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IKBKAP

Summary

InnateDB Gene

IDBG-637400.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IKBKAP

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004991

Encoded Proteins

IDBP-689463

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070061:
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:100163708-100212829

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006570

ENSBTAP00000006570

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008607	phosphorylase kinase regulator activity

Biological Process

GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0030335	positive regulation of cell migration
GO:0045859	regulation of protein kinase activity

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0008023	transcription elongation factor complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0033588	Elongator holoenzyme complex