Version 5.4
Bos taurus Gene: PIP4K2A
Summary
InnateDB Gene IDBG-637633.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIP4K2A
Gene Name phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018033
Encoded Proteins
IDBP-689659
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150867:
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:23900873-24085889
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024007 ENSBTAP00000024007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016307 phosphatidylinositol phosphate kinase activity
Biological Process
GO:0035855 megakaryocyte development
GO:0046488 phosphatidylinositol metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000150867
View Gene Order
ENSMUSG00000026737
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_198973
Synthesis of PIPs at the plasma membrane pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MHR4
UniProt Splice Variant
Entrez Gene 533289
UniGene Bt.18751 Bt.99837
RefSeq NM_001192769
HUGO HGNC:8997
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02035445
GenPept
RNA Seq Atlas 533289

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca