InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pip4k2a

Summary

InnateDB Gene

IDBG-139915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pip4k2a

Gene Name

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Synonyms

AW742916; Pip5k2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026737

Encoded Proteins

IDBP-139917

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

IDBP-535729

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

IDBP-531504

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150867:
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:18842255-18998126

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006912	ENSMUSP00000006912
ENSMUST00000148583	ENSMUSP00000115475
ENSMUST00000152981	ENSMUSP00000119075

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity