Version 5.4
| Bos taurus Gene: CRKL | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-637664.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | CRKL | ||||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Gene | ENSBTAG00000045548 | ||||||||||||||
| Encoded Proteins |
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||
| Summary |
[Homo sapiens] A type-I-IFN receptor that functions as a nuclear adapter protein and associates with STAT5 to regulate gene transcription through DNA binding
[Homo sapiens] Enterohemorrhagic E. coli NleH1 effector targets CRKL to inhibit ribosomal protein S3 nuclear translocation and the NFκB pathway.
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| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099942:
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 17:74286482-74297800 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | |||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL5 pathway
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| REACTOME |
Regulation of signaling by CBL pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Frs2-mediated activation pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signalling by NGF pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Immune System pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Prolonged ERK activation events pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Downstream signal transduction pathway
Frs2-mediated activation pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Signalling by NGF pathway
Signaling by PDGF pathway
NGF signalling via TRKA from the plasma membrane pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Prolonged ERK activation events pathway
Regulation of signaling by CBL pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Chronic myeloid leukemia pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Insulin signaling pathway pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Chronic myeloid leukemia pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Reelin signaling pathway
IGF1 pathway
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
PDGFR-alpha signaling pathway
IFN-gamma pathway
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| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | G3N016 | ||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | |||||||||||||||
| UniGene | |||||||||||||||
| RefSeq | |||||||||||||||
| HUGO | HGNC:2363 | ||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | DAAA02045736 DAAA02045737 | ||||||||||||||
| GenPept | |||||||||||||||
| RNA Seq Atlas | |||||||||||||||