Homo sapiens Gene: CRKL
Summary
InnateDB Gene IDBG-1833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRKL
Gene Name v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099942
Encoded Proteins
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
A type-I-IFN receptor that functions as a nuclear adapter protein and associates with STAT5 to regulate gene transcription through DNA binding
Enterohemorrhagic E. coli NleH1 effector targets CRKL to inhibit ribosomal protein S3 nuclear translocation and the NFκB pathway.
Entrez Gene
Summary This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20917426-20953749
Strand Forward strand
Band q11.21
Transcripts
ENST00000354336 ENSP00000346300
ENST00000411769 ENSP00000396646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 110 [view]
Protein-Protein 109 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001568 blood vessel development
GO:0007254 JNK cascade
GO:0007265 Ras protein signal transduction
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009967 positive regulation of signal transduction
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048538 thymus development
GO:0060017 parathyroid gland development
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL5 pathway
REACTOME
Signalling by NGF pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Frs2-mediated activation pathway
Signal Transduction pathway
Immune System pathway
Downstream signal transduction pathway
Signaling by Interleukins pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Prolonged ERK activation events pathway
Signaling by PDGF pathway
Regulation of signaling by CBL pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Chronic myeloid leukemia pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
Inhibition of cellular proliferation by gleevec [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Integrin signaling pathway [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Reelin signaling pathway
IGF1 pathway
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
PDGFR-alpha signaling pathway
IFN-gamma pathway
Cross-References
SwissProt P46109
TrEMBL
UniProt Splice Variant
Entrez Gene 1399
UniGene Hs.5613 Hs.600046
RefSeq NM_005207
HUGO HGNC:2363
OMIM 602007
CCDS CCDS13785
HPRD
IMGT
EMBL AK292909 BC043500 CH471176 CR456423 X59656
GenPept AAH43500 BAF85598 CAA42199 CAG30309 EAX02932 EAX02933 EAX02934
RNA Seq Atlas 1399