InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BCOR

Summary

InnateDB Gene

IDBG-638074.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCOR

Gene Name

BCL-6 corepressor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000047339

Encoded Proteins

IDBP-690119

BCL6 corepressor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183337:
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:108883915-108907652

Strand

Forward strand

Band

Transcripts

ENSBTAT00000065036

ENSBTAP00000055662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031072	heat shock protein binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000415	negative regulation of histone H3-K36 methylation
GO:0007507	heart development
GO:0030502	negative regulation of bone mineralization
GO:0035518	histone H2A monoubiquitination
GO:0042476	odontogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0060021	palate development
GO:0065001	specification of axis polarity
GO:0070171	negative regulation of tooth mineralization

Cellular Component

GO:0005634	nucleus
GO:0031519	PcG protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000183337

View Gene Order

ENSMUSG00000040363

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classii_pathway

Signaling events mediated by HDAC Class II

Cross-References

SwissProt

TrEMBL

G3X8E4

UniProt Splice Variant

Entrez Gene

784529

UniGene

Bt.18938 Bt.36170

RefSeq

NM_001191544 XM_002706030 XM_005199834 XM_005199835 XM_005199836 XM_005199837 XM_005199838 XM_005199839 XM_005199840 XM_005228295 XM_005228296 XM_005228297

HUGO

HGNC:20893

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02073654

GenPept

RNA Seq Atlas

541088 784529

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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