Bos taurus Gene: MPST
Summary
InnateDB Gene IDBG-638125.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPST
Gene Name 3-mercaptopyruvate sulfurtransferase isoform 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000030648
Encoded Proteins
3-mercaptopyruvate sulfurtransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128309:
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:75818030-75827375
Strand Forward strand
Band
Transcripts
ENSBTAT00000043315 ENSBTAP00000040892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004792 thiosulfate sulfurtransferase activity
GO:0016740 transferase activity
GO:0016784 3-mercaptopyruvate sulfurtransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cysteine and methionine metabolism pathway
Sulfur metabolism pathway
Sulfur relay system pathway
Cysteine and methionine metabolism pathway
Sulfur metabolism pathway
Sulfur relay system pathway
INOH
Methionine Cysteine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.21634
RefSeq NM_001034291 NM_001244324 XM_001249852 XM_005200182 XM_005200183 XM_005200184 XM_005206810 XM_005206811
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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