Homo sapiens Gene: MPST
Summary
InnateDB Gene IDBG-6249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPST
Gene Name mercaptopyruvate sulfurtransferase
Synonyms MST; TST2;
Species Homo sapiens
Ensembl Gene ENSG00000128309
Encoded Proteins
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
mercaptopyruvate sulfurtransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37019635-37029822
Strand Forward strand
Band q12.3
Transcripts
ENST00000341116 ENSP00000342333
ENST00000397225 ENSP00000380402
ENST00000401419 ENSP00000384812
ENST00000404802 ENSP00000383950
ENST00000404393 ENSP00000385062
ENST00000429360 ENSP00000411719
ENST00000485587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004792 thiosulfate sulfurtransferase activity
GO:0016784 3-mercaptopyruvate sulfurtransferase activity
Biological Process
GO:0008152 metabolic process
GO:0009440 cyanate catabolic process
GO:0009636 response to toxic substance
GO:0070814 hydrogen sulfide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cysteine and methionine metabolism pathway
Sulfur metabolism pathway
Sulfur relay system pathway
INOH
Methionine Cysteine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P25325
TrEMBL Q2VEU0 Q2VEU1
UniProt Splice Variant
Entrez Gene 4357
UniGene Hs.248267
RefSeq NM_001013436 NM_001130517 NM_021126 XM_005261610
HUGO HGNC:7223
OMIM 602496
CCDS CCDS13939
HPRD 11896
IMGT
EMBL AK055733 BC003508 BC016737 BC018717 BT019636 CH471095 CR456523 CR541712 DQ211531 DQ211532 DQ211533 X59434 Z73420
GenPept AAH03508 AAH16737 AAH18717 AAV38442 ABB16334 ABB16335 ABB16336 BAG51564 CAA42060 CAG30409 CAG46513 EAW60133 EAW60134 EAW60135
RNA Seq Atlas 4357