Version 5.4
Bos taurus Gene: BT.20969
Summary
InnateDB Gene IDBG-638259.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20969
Gene Name phosphatidylethanolamine N-methyltransferase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016432
Encoded Proteins
IDBP-690328
phosphatidylethanolamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133027:
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35389675-35420462
Strand Forward strand
Band
Transcripts
ENSBTAT00000043580 ENSBTAP00000041140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008170 N-methyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000133027
View Gene Order
ENSMUSG00000000301
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121238
Synthesis of PC pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
mmu00564
Glycerophospholipid metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL G5E5Y7
UniProt Splice Variant
Entrez Gene 360197
UniGene Bt.20969
RefSeq NM_182989
HUGO HGNC:8830
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049007 DAAA02049008
GenPept
RNA Seq Atlas 360197

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca