Homo sapiens Gene: PEMT
Summary
InnateDB Gene IDBG-33054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEMT
Gene Name phosphatidylethanolamine N-methyltransferase
Synonyms PEAMT; PEMPT; PEMT2; PNMT;
Species Homo sapiens
Ensembl Gene ENSG00000133027
Encoded Proteins
phosphatidylethanolamine N-methyltransferase
phosphatidylethanolamine N-methyltransferase
phosphatidylethanolamine N-methyltransferase
phosphatidylethanolamine N-methyltransferase
phosphatidylethanolamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:17505563-17591708
Strand Reverse strand
Band p11.2
Transcripts
ENST00000255389 ENSP00000255389
ENST00000395783 ENSP00000379129
ENST00000395782 ENSP00000379128
ENST00000395781 ENSP00000379127
ENST00000435340 ENSP00000391288
ENST00000421096
ENST00000490392
ENST00000484838
ENST00000477595
ENST00000472446
ENST00000461404 ENSP00000463713
ENST00000582268
ENST00000580147 ENSP00000463112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0004608 phosphatidylethanolamine N-methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008283 cell proliferation
GO:0032259 methylation
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PC pathway
Phospholipid metabolism pathway
Metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
INOH
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UBM1
TrEMBL
UniProt Splice Variant
Entrez Gene 10400
UniGene
RefSeq NM_007169 NM_001267551 NM_001267552 NM_148172 NM_148173 XM_006721418
HUGO HGNC:8830
OMIM 602391
CCDS CCDS11187 CCDS11186 CCDS58520
HPRD 03862
IMGT
EMBL AB029821 AC020558 AF113126 AF176806 AF176807 AF294463 AF294464 AF294465 AF294466 AF294467 AF294468 AK302251 BC000557 BC050593 CH471196 CR457099 EU574003
GenPept AAD53291 AAD53292 AAF14867 AAH00557 AAH50593 AAK19172 ACB21050 BAA82407 BAG63603 CAG33380 EAW55701 EAW55702
RNA Seq Atlas 10400