Version 5.4
Bos taurus Gene: HOGA1
Summary
InnateDB Gene IDBG-638436.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOGA1
Gene Name Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Synonyms C10orf65; DHDPSL; NPL2
Species Bos taurus
Ensembl Gene ENSBTAG00000012721
Encoded Proteins
IDBP-690502
Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241935:
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:18636695-18658208
Strand Forward strand
Band
Transcripts
ENSBTAT00000016909 ENSBTAP00000016909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0008152 metabolic process
GO:0009436 glyoxylate catabolic process
GO:0019470 4-hydroxyproline catabolic process
GO:0033609 oxalate metabolic process
GO:0042866 pyruvate biosynthetic process
GO:0046487 glyoxylate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000025176
View Gene Order
ENSG00000241935
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
mmu00330
Arginine and proline metabolism pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
hsa00330
Arginine and proline metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.54337
RefSeq NM_001075237
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca