InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MBTPS2

Summary

InnateDB Gene

IDBG-638490.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBTPS2

Gene Name

Membrane-bound transcription factor site-2 protease

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008183

Encoded Proteins

IDBP-690559

Membrane-bound transcription factor site-2 protease

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000012174:
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:128669636-128713850

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010764

ENSBTAP00000010764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding