Version 5.4
Bos taurus Protein: MBTPS2
Summary
InnateDB Protein IDBP-690559.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBTPS2
Protein Name Membrane-bound transcription factor site-2 protease
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010764
InnateDB Gene IDBG-638490 (MBTPS2)
Protein Structure
UniProt Annotation
Function Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001193 Membrane-bound transcription factor site-2 protease
IPR001478 PDZ domain
IPR008915 Peptidase M50
PFAM PF00595
PF13180
PF02163
PRINTS PR01000
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0III2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 533134
UniGene Bt.38187
RefSeq NP_001069449
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122628
GenPept AAI22629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca