Version 5.4
Bos taurus Gene: ASPM
Summary
InnateDB Gene IDBG-638531.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASPM
Gene Name abnormal spindle-like microcephaly-associated protein homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007860
Encoded Proteins
IDBP-690675
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066279:
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:77923530-77988157
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010340 ENSBTAP00000010340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001764 neuron migration
GO:0002052 positive regulation of neuroblast proliferation
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0021873 forebrain neuroblast division
GO:0045665 negative regulation of neuron differentiation
GO:0045769 negative regulation of asymmetric cell division
GO:0048477 oogenesis
GO:0048589 developmental growth
GO:0051661 maintenance of centrosome location
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0030496 midbody
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000066279
View Gene Order
ENSMUSG00000033952
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.68506
RefSeq NM_001206506 XM_005217372
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca